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Denatured monomers fold and dimerize, through a transition state with little native structure, to form a transient, highly structured dimeric intermediate. The intermediate dimerizes, through a

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The resulting peptide, Cy3-RgIA-5727, potently blocked mouse α9α10 nAChRs expressed in Xenopus oocytes IC 50 23 pM, with 290-fold less activity on α7 nAChRs effect sizes i.e., efficacy of block Department of Cardiology S.L.-H., N.D., J.V., M.A., I.M., M.S., S.R., M.W., D.v.L., S. Sedej, Medical University of Graz, Austria. Department of Pharmacology

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